8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with <i>MYC</i>

Abstract

The 8q24 gene desert contains risk loci for multiple epithelial cancers, including colon, breast, and prostate. Recent evidence suggests these risk loci contain enhancers. In this study, data are presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific. We therefore propose that the 8q24 risk loci operate through a common mechanism—as tissue-specific enhancers of MYC .

Keywords

EnhancerBiologyLocus (genetics)Prostate cancerEpigeneticsGeneticsChromatinProstateBreast cancerGeneOncogeneCancer researchCancerTranscription factor

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Publication Info

Year: 2010
Type: article
Volume: 107
Issue: 21
Pages: 9742-9746
Citations: 364
Access: Closed

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APA Style

                            
                                
                                    Nasim Ahmadiyeh, 
                                
                                    Mark M. Pomerantz, 
                                
                                    Chiara Grisanzio
                                
                                et al.
                            
                            (2010). 
                            8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with <i>MYC</i>. 
                            Proceedings of the National Academy of Sciences
                            , 107
                            (21)
                            , 9742-9746.
                            https://doi.org/10.1073/pnas.0910668107
                        

Identifiers

DOI: 10.1073/pnas.0910668107