Abstract
Superoxide dismutase inhibited the autoxidation of 6-hydroxydopamine as measured by the rate of formation of a quinone and the rate of oxygen consumption. These observations demonstrate the formation of the superoxide radical during the autoxidation process. This finding may be relevant to the mechanism of adrenergic nerve terminal degeneration caused by 6-hydroxydopamine.
Keywords
AutoxidationHydroxydopamineSuperoxideChemistrySuperoxide dismutaseSuperoxide radicalOxidative phosphorylationOxygenBiochemistryOxidative stressEndocrinologyBiologyOrganic chemistryEnzymeDopamine
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Publication Info
- Year
- 1973
- Type
- article
- Volume
- 181
- Issue
- 4098
- Pages
- 456-457
- Citations
- 257
- Access
- Closed
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Cite This
Richard E. Heikkila,
Gerald Cohen
(1973).
6-Hydroxydopamine: Evidence for Superoxide Radical as an Oxidative Intermediate.
Science
, 181
(4098)
, 456-457.
https://doi.org/10.1126/science.181.4098.456
Identifiers
- DOI
- 10.1126/science.181.4098.456