3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets

Amanda Birmingham; Emily M. Anderson; Angela Reynolds; Diane Ilsley-Tyree; Devin Leake; Yuriy Fedorov; Scott Baskerville; Elena Maksimova; Kathryn M. Robinson; Jon Karpilow; William S. Marshall; Anastasia Khvorova

doi:10.1038/nmeth854

Keywords

RNA interferenceSmall interfering RNAGene silencingBiologyGeneUntranslated regionComputational biologyGeneticsTrans-acting siRNARandom hexamerGene expressionRNA silencingThree prime untranslated regionTransfectionRNACell biologyMolecular biology

Affiliated Institutions

Agilent Technologies (United States) US

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Publication Info

Year: 2006
Type: article
Volume: 3
Issue: 3
Pages: 199-204
Citations: 873
Access: Closed

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APA Style

                            
                                
                                    Amanda Birmingham, 
                                
                                    Emily M. Anderson, 
                                
                                    Angela Reynolds
                                
                                et al.
                            
                            (2006). 
                            3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets. 
                            Nature Methods
                            , 3
                            (3)
                            , 199-204.
                            https://doi.org/10.1038/nmeth854
                        

Identifiers

DOI: 10.1038/nmeth854