β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB

Eduard Batlle; Jeffrey T. Henderson; Harry Beghtel; Maaike M.W. van den Born; Elena Sancho; Gerwin Huls; Jan Meeldijk; Jennifer Robertson; Marc van de Wetering; Tony Pawson; Hans Clevers

doi:10.1016/s0092-8674(02)01015-2

Keywords

BiologyCryptIntestinal epitheliumCell biologyEphrinEpitheliumWnt signaling pathwayCateninPaneth cellStem cellCellCell migrationEndocrinologySignal transductionGeneticsSmall intestine

Affiliated Institutions

Related Publications

Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium

Pauline Bastide , Charbel Darido , Julie Pannequin +9 more

The HMG-box transcription factor Sox9 is expressed in the intestinal epithelium, specifically, in stem/progenitor cells and in Paneth cells. Sox9 expression requires an active β...

2007 The Journal of Cell Biology 465 citations

Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1

Frank Kuhnert , Corrine R. Davis , Hsiao-Ting Wang +5 more

Whereas the adult gastrointestinal epithelium undergoes tremendous self-renewal through active proliferation in crypt stem cell compartments, the responsible growth factors regu...

2003 Proceedings of the National Academy o... 613 citations

Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium

Kyung‐Ah Kim , Makoto Kakitani , Jingsong Zhao +9 more

Several described growth factors influence the proliferation and regeneration of the intestinal epithelium. Using a transgenic mouse model, we identified a human gene, R-spondin...

2005 Science 575 citations

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

Daniel Pinto , Alex Gregorieff , Harry Begthel +1 more

To assess the critical role of Wnt signals in intestinal crypts, we generated transgenic mice ectopically expressing Dickkopf1 (Dkk1), a secreted Wnt inhibitor. We find that epi...

2003 Genes & Development 1003 citations

Targeting the Wnt/β-catenin signaling pathway in cancer

Ya Zhang , Xin Wang

Abstract The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell proliferation and differentiation, thus exerting crucial roles in tumorigenesis ...

2020 Journal of Hematology & Oncology 1329 citations

Publication Info

Year: 2002
Type: article
Volume: 111
Issue: 2
Pages: 251-263
Citations: 1100
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1100

OpenAlex

Cite This

APA Style

                            
                                
                                    Eduard Batlle, 
                                
                                    Jeffrey T. Henderson, 
                                
                                    Harry Beghtel
                                
                                et al.
                            
                            (2002). 
                            β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB. 
                            Cell
                            , 111
                            (2)
                            , 251-263.
                            https://doi.org/10.1016/s0092-8674(02)01015-2
                        

Identifiers

DOI: 10.1016/s0092-8674(02)01015-2