University of Washington Medical Center

Design and validation of a histological scoring system for nonalcoholic fatty liver disease†

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in the absence of a history of significant alcohol use or other known liver disease. Nonalcoholic ...

The landscape of somatic copy-number alteration across human cancers

Tau is a candidate gene for chromosome 17 frontotemporal dementia

Abstract Frontotemporal dementia with parkinsonism, chromosome 17 type (FTDP‐17), a recently defined disease entity, is clinically characterized by personality changes sometimes...

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

Linkage analysis was used to search the genome for chromosomal regions harboring familial Alzheimer's disease genes. Markers on chromosome 14 gave highly significant positive lo...

A Multifaceted Intervention to Improve Treatment of Depression in Primary Care

This research study evaluates the effectiveness of a multifaceted intervention program to improve the management of depression in primary care.One hundred fifty-three primary ca...

The Genetic Basis of Mendelian Phenotypes: Discoveries, Challenges, and Opportunities

Genome-scale mapping of DNase I sensitivity in vivo using tiling DNA microarrays

Patients' and family members' views on how clinicians enact and how they should enact incident disclosure: the "100 patient stories" qualitative study

Despite growing prominence of open disclosure, discussion about healthcare incidents still falls short of patient and family member expectations. Healthcare organisations and pr...