University of Minnesota Medical Center

Structure, Function, and Evolution of Coronavirus Spike Proteins

The coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. It first binds to a receptor on the host cell surface throu...

RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

Neurofibrillary tangles (NFTs) are the most common intraneuronal inclusion in the brains of patients with neurodegenerative diseases and have been implicated in mediating neuron...

Age-Dependent Neurofibrillary Tangle Formation, Neuron Loss, and Memory Impairment in a Mouse Model of Human Tauopathy (P301L)

Here, we describe the generation of a novel transgenic mouse model of human tauopathy. The rTg(tau P301L )4510 mouse expresses the P301L mutation in tau (4R0N) associated with f...

Lifetime Risk of Atrial Fibrillation by Race and Socioeconomic Status

Background: Limited information exists on the lifetime risk of atrial fibrillation (AF) in African Americans and by socioeconomic status. Methods: We studied 15 343 participants...

American Heart Association's Life's Simple 7: Avoiding Heart Failure and Preserving Cardiac Structure and Function