Tiburon Associates (United States)

Search and clustering orders of magnitude faster than BLAST

Abstract Motivation: Biological sequence data is accumulating rapidly, motivating the development of improved high-throughput methods for sequence classification. Results: UBLAS...

UPARSE: highly accurate OTU sequences from microbial amplicon reads

Error filtering, pair assembly and error correction for next-generation sequencing reads

Abstract Motivation: Next-generation sequencing produces vast amounts of data with errors that are difficult to distinguish from true biological variation when coverage is low. ...

Stability of operational taxonomic units: an important but neglected property for analyzing microbial diversity

As a compromise to the factors listed above, we propose using an open-reference method to enhance OTU stability. This type of method clusters sequences against a database and in...