St George's Hospital

Measuring agreement in method comparison studies

Agreement between two methods of clinical measurement can be quantified using the differences between observations made using the two methods on the same subjects. The 95% limit...

Comparing methods of measurement: why plotting difference against standard method is misleading

A note on the use of the intraclass correlation coefficient in the evaluation of agreement between two methods of measurement

The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

This review describes the structure and function of the interferon (IFN)-inducible, double-stranded RNA-activated protein kinase PKR. This protein kinase has been studied extens...

Role of Heat Shock Proteins in Atherosclerosis

Heat shock proteins (HSPs) are present in most cells, serving as molecular chaperones, and they play a role in cell protection from damage in response to stress stimuli. However...

Intensive versus standard case management for severe psychotic illness: a randomised trial

A Study of Human Leukocyte D Locus Related Antigens in Graves' Disease

An association between Graves' disease and the human leukocyte antigen (HLA) system has previously been reported. The disease was more strongly associated with the HLA D locus a...