Shanghai Institutes for Biological Sciences

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

The Biogenesis, Functions, and Challenges of Circular RNAs

Covalently closed circular RNAs (circRNAs) are produced by precursor mRNA back-splicing of exons of thousands of genes in eukaryotes. circRNAs are generally expressed at low lev...

Efficient generation of mouse models of human diseases via ABE- and BE-mediated base editing

Abstract A recently developed adenine base editor (ABE) efficiently converts A to G and is potentially useful for clinical applications. However, its precision and efficiency in...

Ferroptosis as a target for protection against cardiomyopathy

Significance Nonapoptotic cell death-induced tissue damage has been implicated in a variety of diseases, including neurodegenerative disorder, inflammation, and stroke. In this ...

COVID-19 infection: the perspectives on immune responses

More than 100 years since the outbreak of the 1918 influenza pandemic, we now seem to face another pandemic. The outbreak of the new coronavirus (SARS-CoV-2) infection is spread...

Structural basis and functional analysis of the SARS coronavirus nsp14–nsp10 complex

Significance Proofreading exonucleases contributing to replication fidelity in DNA viruses and cellular organisms are well known; however, proofreading in RNA viruses was unknow...

Optimizing de novo transcriptome assembly from short-read RNA-Seq data: a comparative study

Abstract Background With the fast advances in nextgen sequencing technology, high-throughput RNA sequencing has emerged as a powerful and cost-effective way for transcriptome st...

Structure of a yeast spliceosome at 3.6-angstrom resolution

Structure and function of the spliceosome When RNA is transcribed from DNA in the eukaryotic cell nucleus, the initial transcript includes noncoding introns that must be spliced...