National Institute of Genetics

A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences

Estimation of evolutionary distances between homologous nucleotide sequences.

By using two models of evolutionary base substitutions--"three-substitution-type" and "two-frequency-class" models--some formulae are derived which permit a simple estimation of...

THE NUMBER OF HETEROZYGOUS NUCLEOTIDE SITES MAINTAINED IN A FINITE POPULATION DUE TO STEADY FLUX OF MUTATIONS

N natural populations, it is expected that there is a constant supply of muta-I tions in each generation.These mutations may have different persistence depending on their fitnes...

Sequence Analysis of the Genome of an Oil-Bearing Tree, Jatropha curcas L.

The whole genome of Jatropha curcas was sequenced, using a combination of the conventional Sanger method and new-generation multiplex sequencing methods. Total length of the non...

Chromosomal Dynamics at the Shh Locus: Limb Bud-Specific Differential Regulation of Competence and Active Transcription

Effective number of alleles in a subdivided population

Archiving next generation sequencing data

Next generation sequencing platforms are producing biological sequencing data in unprecedented amounts. The partners of the International Nucleotide Sequencing Database Collabor...

In silico protein interaction screening uncovers DONSON’s role in replication initiation

CDC45-MCM2-7-GINS (CMG) helicase assembly is the central event in eukaryotic replication initiation. In yeast, a multi-subunit “pre-loading complex” (pre-LC) accompanies GINS to...

A Ubiquitin-Conjugating Enzyme in Fission Yeast That Is Essential for the Onset of Anaphase in Mitosis

A cDNA encoding a ubiquitin-conjugating enzyme designated UbcP4 in fission yeast was isolated. Disruption of its genomic gene revealed that it was essential for cell viability. ...