Institute for Integrative and Experimental Genomics

Statistical significance for genomewide studies

With the increase in genomewide experiments and the sequencing of multiple genomes, the analysis of large data sets has become commonplace in biology. It is often the case that ...

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

Abstract During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker resear...

Large-scale association analysis identifies new risk loci for coronary artery disease

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching geno...

Class II HLA interactions modulate genetic risk for multiple sclerosis