Children's Hospital of Philadelphia

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

The basic composition of the human gut microbiome is influenced by long-term diet: high fat and protein versus high fiber.

Mutational heterogeneity in cancer and the search for new cancer-associated genes

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

In this global study of CAR T-cell therapy, a single infusion of tisagenlecleucel provided durable remission with long-term persistence in pediatric and young adult patients wit...

Mendelian randomization of blood lipids for coronary heart disease

The genetic findings support a causal effect of triglycerides on CHD risk, but a causal role for HDL-C, though possible, remains less certain.

In vivo genome editing restores haemostasis in a mouse model of haemophilia

Mendelian Randomization in the Era of Genomewide Association Studies

Abstract Background: Observational epidemiology has been instrumental in identifying modifiable causes of common diseases, and, in turn, substantially impacting public health. S...

Islet-1 Regulates Arx Transcription during Pancreatic Islet α-Cell Development

Aristaless related homeodomain protein (Arx) specifies the formation of the pancreatic islet α-cell during development. This cell type produces glucagon, a major counteracting h...