Boston College

The Sequence Alignment/Map format and SAMtools

Abstract Summary: The Sequence Alignment/Map (SAM) format is a generic alignment format for storing read alignments against reference sequences, supporting short and long reads ...

The Lancet Commission on pollution and health

Instrumental Variables and GMM: Estimation and Testing

We discuss instrumental variables (IV) estimation in the broader context of the generalized method of moments (GMM), and describe an extended IV estimation routine that provides...

ART: a next-generation sequencing read simulator

Abstract Summary: ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools f...

Were the Good Old Days That Good? Changes in Managerial Stock Ownership Since the Great Depression

We document that ownership by officers and directors of publicly traded firms is on average higher today than earlier in the century. Managerial ownership has risen from 13 perc...

Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4.

Newly synthesized histone H4 is deposited in a diacetylated isoform in a wide variety of organisms. In Tetrahymena a specific pair of residues, lysines 4 and 11, have been shown...

Dynamic development of psychological structures in action and thought.

The origins and ends of giftedness.

Five issues about giftedness are discussed. First, the origins of giftedness are explored. The view that giftedness is entirely a product of training is critiqued. There is indi...

Demeaning Conditioning Diagnostics through Centering

Abstract It is often thought that regression data should be mean-centered before being diagnosed for collinearity (ill conditioning). This view is shown not generally to be corr...

Ready-to-wear: Discovering grounded formal theory

As qualitative methods have become popular and qualitative reports abundant, researchers have begun to discuss techniques for synthesizing findings about related phenomena from ...