Toren Finkel

Oxidants, oxidative stress and the biology of ageing

Oxygen radicals and signaling

Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism

Leakage of mitochondrial oxidants contributes to a variety of harmful conditions ranging from neurodegenerative diseases to cellular senescence. We describe here, however, a phy...

Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species

Human diploid fibroblasts eventually lose the capacity to replicate in culture and enter a viable but nonproliferative state of senescence. Recently, it has been demonstrated th...

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

Reactive oxygen species (ROS) have been implicated as potential modulators of apoptosis. Conversely, experiments under hypoxic conditions have suggested that apoptosis could occ...