Tom van der Poll

Sepsis: a roadmap for future research

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

These updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earl...

Interleukin-6 Stimulates Coagulation, not Fibrinolysis, in Humans

Summary The role of IL-6 as a mediator of haemostatic changes during severe inflammation is controversial. To assess the effect of IL-6 on haemostasis we conducted a controlled ...

Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

In this retrospective analysis of data sets from patients with sepsis, 4 clinical phenotypes were identified that correlated with host-response patterns and clinical outcomes, a...