Shelley L. Berger

Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide

Catalytic Mechanism and Function of Invariant Glutamic Acid 173 from the Histone Acetyltransferase GCN5 Transcriptional Coactivator

Within chromatin, reversible acetylation of core histones is critical for transcriptional activation of eukaryotic target genes. The recent identification of intrinsic histone a...

Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator

The yeast GCN5 (yGCN5) transcriptional coactivator functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Here, we present the high resolution cry...

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional changes co...