Lina Chen

Mutational Processes Molding the Genomes of 21 Breast Cancers

A comprehensive catalogue of somatic mutations from a human cancer genome

All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth advantage and are implicated in cancer development, ...

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

A small-cell lung cancer genome with complex signatures of tobacco exposure

Signatures of mutation and selection in the cancer genome

The cancer genome is moulded by the dual processes of somatic mutation and selection. Homozygous deletions in cancer genomes occur over recessive cancer genes, where they can co...