Kenneth W. Kinzler

High Frequency of Mutations of the <i>PIK3CA</i> Gene in Human Cancers

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Mutational Analysis of the Tyrosine Kinome in Colorectal Cancers

Tyrosine kinases (TKs) are central regulators of signaling pathways that control differentiation, transcription, cell cycle progression, apoptosis, motility, and invasion ( [1][...

A model for p53-induced apoptosis

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

This study showed that mismatch-repair status predicted clinical benefit of immune checkpoint blockade with pembrolizumab. (Funded by Johns Hopkins University and others; Clinic...

Incidence and functional consequences of <i>hMLH1</i> promoter hypermethylation in colorectal carcinoma

Inactivation of the genes involved in DNA mismatch repair is associated with microsatellite instability (MSI) in colorectal cancer. We report that hypermethylation of the 5′ CpG...

Cancer Genome Landscapes

Over the past decade, comprehensive sequencing efforts have revealed the genomic landscapes of common forms of human cancer. For most cancer types, this landscape consists of a ...

The Consensus Coding Sequences of Human Breast and Colorectal Cancers

The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alte...

The Genomic Landscapes of Human Breast and Colorectal Cancers

Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalog the genetic changes that occur during tumorigenesis, we isolated DNA ...

Clues to the Pathogenesis of Familial Colorectal Cancer

A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in some families. Molecular features of "familial" cancers were compared with those of spo...

Hypermutability and mismatch repair deficiency in RER+ tumor cells

Somatic mutations in the chromatin remodeling gene <i>ARID1A</i> occur in several tumor types

Mutations in the chromatin remodeling gene ARID1A have recently been identified in the majority of ovarian clear cell carcinomas (OCCCs). To determine the prevalence of mutation...

Definition of a consensus binding site for p53

Identification of p53 as a Sequence-Specific DNA-Binding Protein

The tumor-suppressor gene p53 is altered by missense mutation in numerous human malignancies. However, the biochemical properties of p53 and the effect of mutation on these prop...

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

Mutant forms of the gene encoding the tumor suppressor p53 are found in numerous human malignancies, but the physiologic function of p53 and the effects of mutations on this fun...

Whole genome PCR: application to the identification of sequences bound by gene regulatory protein

A strategy is described that allows the isolation of DNA sequences that can bind to gene regulatory proteins. Total genomic DNA is first converted to a form that is suitable for...