James Torrance

The complete sequence of a human genome

Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addr...

Significantly improving the quality of genome assemblies through curation

Abstract Genome sequence assemblies provide the basis for our understanding of biology. Generating error-free assemblies is therefore the ultimate, but sadly still unachieved go...

Towards complete and error-free genome assemblies of all vertebrate species

MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio high fidelity reads

Background  PacBio high fidelity (HiFi) sequencing reads are both long (15–20 kb) and highly accurate (> Q20). Because of these properties, they have revolutionised genome assem...