Publications
3 shownTranscriptional Pathway Signatures Predict MEK Addiction and Response to Selumetinib (AZD6244)
Abstract Selumetinib (AZD6244, ARRY-142886) is a selective, non–ATP-competitive inhibitor of mitogen-activated protein/extracellular signal–regulated kinase kinase (MEK)-1/2. Th...
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
Tumors with mutant BRAF and some with mutant RAS are dependent upon ERK signaling for proliferation, and their growth is suppressed by MAPK/ERK kinase (MEK) inhibitors. In contr...
Frequent Co-Authors
Researcher Info
- h-index
- 3
- Publications
- 3
- Citations
- 1,151
- Institution
- QIMR Berghofer Medical Research Institute
External Links
Identifiers
- ORCID
- 0000-0002-3355-9471
Impact Metrics
h-index
3
h-index: Number of publications with at least h citations each.