Allan Bradley

Requirement for Wnt3 in vertebrate axis formation

Requirement of <i>bic/microRNA-155</i> for Normal Immune Function

MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalia...

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

The Wnt-1 (int-1) proto-oncogene, which encodes a putative signaling molecule, is expressed exclusively in the developing central nervous system and adult testes. To examine the...

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.

By crossing mice that carry a null allele of p53 with transgenic mice that develop mammary adenocarcinomas under the influence of a Wnt-1 transgene, we have studied the conseque...